@article{Gurgel_Oliveira_Leitão_Barroso_Pitombeira_Duarte_Duarte_Duarte_Duarte_2021, title={Overall survival in patients with acute lymphoblastic leukemia treated with CALGB 8811 protocol in low income country}, volume={2}, url={https://www.jbmtct.com.br/seer/index.php/jbmtct/article/view/95}, DOI={10.46765/2675-374X.2021v2n2p95}, abstractNote={<p>Introduction: ALL is known to have a lower survival rate in adults and this can be attributed, among other aspects, to intolerance to intensive regimens. As the treatment of ALL is very complex, with many protocols available, this study proposes an analysis regarding the CALGB 8811 protocol in a tertiary health unit in Ceará</p> <p>Methods: In this retrospective study, 50 patients with a recent diagnosis of ALL who underwent the CALGB8811 protocol were evaluated. Disease risk criteria were based on the CALGB8811 protocol.</p> <p>Results: CR was obtained in 86% of patients. 12% of patients died during induction due to infectious complications. 30% of patients underwent alloSCT, 60% were on CR1.</p> <p>The median overall survival (OS) was 21.5 months (8.1-38.7). The 5 years OS was 25% in the transplanted patients versus 60% in the transplanted group. Achieving complete remission after induction chemotherapy and allogeneic hematopoietic stem cell transplantation were the factors associated with better long-term survival rates in uni and multivariate analysis.</p> <p>Conclusion: Risk factors classically associated with worse adult ALL outcome and post-induction MRD status were not outcome predictors, in addition, post-induction remission and alloSCT were factors associated with a favorable outcome.</p>}, number={2}, journal={JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY}, author={Gurgel, Livia Andrade and Oliveira, Deivide de sousa and Leitão, João Paulo Vasconcelos and Barroso, Karine Sampaio Nunes and Pitombeira, Beatriz Stella Gomes de Souza and Duarte, Isabella Araujo and Duarte, João Vitor Araujo and Duarte, Beatrice Araujo and Duarte, Fernando Barroso}, year={2021}, month={Jul.}, pages={p95} }