Acute and Chronic Graft-Versus-Host-Disease – A Focus on Pediatric Patients


  • Antonio Vaz de Macedo
  • Júlia Garcia Hematopoietic Stem Cell Transplantation Unit, Instituto de Tratamento do Câncer Infantil, Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil
  • Roseane Gouveia Pediatric Bone Marrow Transplant Unit, Hospital Samaritano, São Paulo, SP, Brazil.
  • Rita de Cássia Tavares Bone Marrow Transplant Center- CEMO, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil



Graft-Versus-Host Disease, Diagnosis, Classification, Grading, Staging, Prophylaxis, Treatment, Hematopoietic Stem Cell Transplantation, Pediatric, Consensus Guidelines


Graft-versus-host disease (GVHD), either in its acute or chronic form, is the main contributory factor for morbidity and non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recent advancements in the classification of this disease, with better applicability and reproducibility of standardized criteria, coupled with improvements in the management of steroid-refractory or resistant cases, have led to promising results. In 2020, the Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society for Blood and Marrow Transplantation and Cellular Therapy (SBTMO) convened a task force to provide updated, evidence-based guidance for the diagnosis, classification, staging, prophylaxis, and treatment of GVHD, with a focus on the pediatric population, the results of which are presented here.





How to Cite

Vaz de Macedo, A., Lopes Garcia, J., Vasconcelos Gouveia, R. ., & Barbosa Tavares, R. de C. (2021). Acute and Chronic Graft-Versus-Host-Disease – A Focus on Pediatric Patients . JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 2(4), 140.